Flies cause nuisance and transmit many diseases to humans as well as for domestic animals. Many fly species interfere with humans life such as; domestic house fly, flesh fly, drain fly, blow fly, etc. Due to their high and fast reproduction rate, flies spread worldwide in human habitat and become difficult to control. Integrated flies control programs were designed based on the living habitat and feeding habit for fly species. Wide range of treatments could be included in flies control program starting from sanitation and cleaning and use of fly traps up to use of several pesticides with different mode of action.